New mpox strain is changing fast; African scientists are ‘working blindly’ to respond

New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
FILE PHOTO: A test tube labelled “Mpox virus positive” is held in this illustration taken August 20, 2024. (REUTERS)
Short Url
Updated 27 August 2024
Follow

New mpox strain is changing fast; African scientists are ‘working blindly’ to respond

New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
  • Scientists say many questions remain about new clade Ib strain
  • Sexual transmission driving spread, but children infected, too

LONDON/CHICAGO: Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected and often in areas where experts lack the funding and equipment to properly track it.
That means there are multiple unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.
Mpox, formerly known as monkeypox, has been a public health problem in parts of Africa since 1970, but received little global attention until it surged internationally in 2022, prompting the World Health Organization to declare a global health emergency. That declaration ended 10 months later.
A new strain of the virus, known as clade Ib, has the world’s attention again after the WHO declared a new health emergency.
The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.
Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.
“I worry that in Africa, we are working blindly,” said Dr. Dimie Ogoina, an infectious diseases expert at Niger Delta University Hospital in Nigeria who chairs the WHO’s mpox emergency committee. He first raised the alarm about potential sexual transmission of mpox in 2017, now an accepted route of spread for the virus.
“We don’t understand our outbreak very well, and if we don’t understand our outbreak very well we will have difficulty addressing the problem in terms of transmission dynamics, the severity of the disease, risk factors of the disease,” Ogoina said. “And I worry about the fact that the virus seems to be mutating and producing new strains.”
He said it took clade IIb in Nigeria five years or more to evolve enough for sustained spread among humans, sparking the 2022 global outbreak. Clade Ib has done the same thing in less than a year.
Mutating ‘more rapidly’
Mpox is an orthopoxvirus, the same family that causes smallpox. Population-wide protection from a global vaccine campaign 50 years ago has waned, as the vaccinating stopped when the disease was eradicated.
Genetic sequencing of clade Ib infections, which the WHO estimates emerged mid-September 2023, show they carry a mutation known as APOBEC3, a signature of adaptation in humans.
The virus that causes mpox has typically been fairly stable and slow to mutate, but APOBEC-driven mutations can accelerate viral evolution, said Dr. Miguel Paredes, who is studying the evolution of mpox and other viruses at Fred Hutchison Cancer Center in Seattle.
“All the human-to-human cases of mpox have this APOBEC signature of mutations, which means that it’s mutating a little bit more rapidly than we would expect,” he said.
Paredes and other scientists said a response was complicated by several mpox outbreaks happening at once.
In the past, mpox was predominantly acquired through human contact with infected animals. That is still driving a rise in Congo in clade I cases – also known as clade Ia — likely due in part to deforestation and increased consumption of bushmeat, scientists said.
The mutated versions, clade Ib and IIb, can now essentially be considered a sexually transmitted disease, said Dr. Salim Abdool Karim, a South African epidemiologist and chair of the Africa CDC’s mpox advisory committee. Most of the mutated clade Ib cases are among adults, driven at first by an epidemic among female sex workers in South Kivu, Congo.
The virus also can spread through close contact with an infected person, which is likely how clusters of children have been infected with clade Ib, particularly in Burundi and in eastern Congo’s displacement camps, where crowded living conditions may be contributing.
Children, pregnant women and people with weakened immune systems may be at greater risk of serious mpox disease and death, according to the WHO.
Clade I has typically caused more severe disease, with fatality rates of 4 percent-11 percent, compared to around 1 percent for clade II. Ogoina said data from Congo suggests few have died of the new Ib version, but he feared some data is being mixed up.
More research is urgently needed, but three teams tracking mpox outbreaks in Africa say they cannot even access chemicals needed for diagnostic tests.
Planning a response, including vaccination strategies, without this is difficult, the scientists said.
Karim said around half of cases in eastern Congo, where Ib is particularly prevalent, are only being diagnosed by doctors, with no laboratory confirmation.
Getting samples to labs is difficult because the health care system is already under pressure, he said. And around 750,000 people have been displaced amid fighting between the M23 rebel group and the government.
Many African laboratories cannot get the supplies they need, said Dr. Emmanuel Nakoune, an mpox expert at the Institut Pasteur in Bangui, Central African Republic, which also has clade Ia cases.
“This is not a luxury,” he said, but necessary to track deadly outbreaks.


UN says shooting incident at Kabul compound killed one

UN says shooting incident at Kabul compound killed one
Updated 16 sec ago
Follow

UN says shooting incident at Kabul compound killed one

UN says shooting incident at Kabul compound killed one
  • UN says gunshots were fired by member of Taliban’s security forces at multilateral agency’s largest compound 
  • Person killed was member of Taliban-run security forces who was outside the compound, unclear what provoked firing

ISLAMABAD: Gunshots fired by a member of the Taliban’s security forces at the United Nations’ largest compound killed one person and injured another in Kabul, the United Nations Assistance Mission in Afghanistan (UNAMA) said in a statement on Monday.

The incident took place on Sunday, it said.

The person killed was a member of the Taliban-run security forces who was outside the compound, the statement said without adding any details. The person injured was an international security guard contracted by the UN, it said.

“UN-contracted security guards did not return fire during the incident,” it said.

It was unclear what provoked the firing. Both the Taliban and the UN were investigating the incident.

Kabul’s interior ministry spokesman Abdul Mateen Qaniee confirmed that a Taliban guard was killed and one UN contractor suffered injuries.

Taliban authorities halted all movement in and out of the compound following the incident, UNAMA said, but those restrictions have now been lifted.

The compound houses the offices of multiple UN agencies, funds and programs, and accommodation for UN international staff members.


Ukrainian troops lose ground with fewer fighters and exposed supply lines

Ukrainian troops lose ground with fewer fighters and exposed supply lines
Updated 03 February 2025
Follow

Ukrainian troops lose ground with fewer fighters and exposed supply lines

Ukrainian troops lose ground with fewer fighters and exposed supply lines
  • Moscow is set on capturing as much territory as possible as the Trump administration is pushing for negotiations to end the war
  • Ukrainian soldiers in Pokrovsk said that Russian forces switched tactics in recent weeks, attacking their flanks instead of going head-on

POKROVSK REGION, Ukraine: A dire shortage of infantry troops and supply routes coming under Russian drone attacks are conspiring against Ukrainian forces in Pokrovsk, where decisive battles in the nearly three-year war are playing out — and time is running short.
Ukrainian troops are losing ground around the crucial supply hub, which lies at the confluence of multiple highways leading to key cities in the eastern Donetsk region as well as an important railway station.
Moscow is set on capturing as much territory as possible as the Trump administration is pushing for negotiations to end the war and recently froze foreign aid to Ukraine, a move that has shocked Ukrainian officials already apprehensive about the intentions of the new US president, their most important ally. Military aid has not stopped, Ukrainian President Volodymyr Zelensky has said.
Ukrainian soldiers in Pokrovsk said that Russian forces switched tactics in recent weeks, attacking their flanks instead of going head-on to form a pincer movement around the city. With Russians in control of dominant heights, Ukrainian supply routes are now within their range. Heavy fog in recent days prevented Ukrainian soldiers from effectively using surveillance drones, allowing Russians to consolidate and take more territory.
Meanwhile, Ukrainian commanders say they do not have enough reserves to sustain defense lines and that new infantry units are failing to execute operations. Many pin hopes on Mykhailo Drapatyi, a respected commander recently appointed by Ukrainian President Volodymyr Zelensky as ground forces chief, to shift the dynamic and counterattack.
“The war is won by logistics. If there is no logistics, there is no infantry, because there is no way to supply it,” said the deputy commander of the Da Vinci Wolves battalion, known by the call sign Afer.
“(Russians) have learned this and are doing it quite well.”
Poor weather at the worst time
A combination of factors led Kyiv to effectively lose the settlement of Velyka Novosilka this past week, their most significant gain since seizing the city of Kurakhove in the Donetsk region in January.
Scattered groups of Ukrainian soldiers are still present in Velyka Novosilka’s southern sector, Ukrainian commanders said, prompting criticism from some military experts who questioned why the higher command did not order a full withdrawal.
The road-junction village is 15 kilometers (9 miles) from the neighboring Dnipropetrovsk region, where authorities have begun digging fortifications for the first time since Russia’s full-scale invasion in February 2022, anticipating further Russian advances.
Russia amassed a large number of infantry around Velyka Novosilka, soldiers there said. As heavy fog set in in recent days, Ukrainian drones “barely worked” to conduct surveillance, one commander near Pokrovsk told The Associated Press. Long-range and medium-range surveillance was impossible, he said. He spoke on condition of anonymity in order to speak freely about sensitive military matters.
“Because of this, the enemy was amassing forces … taking up positions, digging in. They were very good at it,” he said.
It was at that fateful moment that Russian forces launched a massive attack: Up to 10 columns of armored vehicles, each with up to 10 units, moved out from various directions.
Ukrainian logistics in peril
Key logistics routes along asphalted roads and highways are under direct threat from Russian drones as a result of Moscow’s recent gains, further straining Ukrainian troops.
Russian forces now occupy key dominant heights around the Pokrovsk region, which allows them to use drones up to 30 kilometers (18 miles) deep into Ukrainian front lines.
The Pokrovsk-Pavlohrad-Dnipro highway is “already under the control of Russian drones,” said the commander at Pokrovsk’s flanks. Russian forces are less than 4 kilometers ( 2 1/2 miles) away and are affecting Ukrainian traffic, he said. “Now the road is only 10 percent of its former capacity,” he said.
Another paved highway, the Myrnohrad-Kostyantynivka road, is also under Russian fire, he said.
This also means that in poor weather, military vehicles, including armored personnel carriers, tanks and pickup trucks, have to trudge through the open fields to deliver fuel, food and ammunition, as well as evacuate the wounded.
In a first-aid station near Pokrovsk, a paramedic with the call sign Marik said evacuating wounded soldiers once took hours, now it takes days.
“Everything is visible (by enemy drones) and it is very difficult,” he said.
New recruits are unprepared
Ukrainian soldiers in Pokrovsk said shortages of fighting troops are “catastrophic” and challenges are compounded by newly created infantry units that are poorly trained and inexperienced, putting more pressure on battle-hardened brigades having to step in to stabilize the front line.
Afer, the deputy commander, complained that new recruits are “constantly extending the front line because they leave their positions, they do not hold them, they do not control them, they do not monitor them. We do almost all the work for them.”
“Because of this, having initially a 2-kilometer area of responsibility, you end up with 8-9 kilometers per battalion, which is a lot and we don’t have enough resources,” Afer said. Drones are especially hard to come by for his battalion, he said, adding they only have half of what they need.
“It’s not because they have lower quality infantry, but because they are completely unprepared for modern warfare,” he said of the new recruits.
His battalion has almost no reserves, forcing infantry units to hold front-line positions for weeks at a time. For every one of his soldiers, Russians have 20, he said, emphasizing how outnumbered they are.
Back at the first-aid station, a wounded soldier with the call sign Fish was recovering from a leg wound sustained after he tried to evacuate a fallen comrade. He had moved him from a dugout to load him into a vehicle when the Russian mortar shell exploded nearby.
“We are fighting back as much as we can, as best as we can,” he said.


South Africa’s Ramaphosa to engage Trump over aid suspension

South Africa’s Ramaphosa to engage Trump over aid suspension
Updated 03 February 2025
Follow

South Africa’s Ramaphosa to engage Trump over aid suspension

South Africa’s Ramaphosa to engage Trump over aid suspension

JOHANNESBURG: South African President Cyril Ramaphosa said on Monday that he looked forward to engaging with US President Donald Trump, after Trump said he would cut off funding for South Africa, citing land confiscations.
“We look forward to engaging with the Trump administration over our land reform policy and issues of bilateral interest. We are certain that out of those engagements, we will share a better and common understanding over these matters,” Ramaphosa said in a statement issued by the presidency.
“South Africa is a constitutional democracy that is deeply rooted in the rule of law, justice and equality. The South African government has not confiscated any land.”
Ramaphosa said except for PEPFAR aid, which constitutes 17 percent of South Africa’s HIV/Aids program, there was no other significant funding provided by the United States.


Pakistan police officer killed as polio vaccination drive starts

Pakistan police officer killed as polio vaccination drive starts
Updated 03 February 2025
Follow

Pakistan police officer killed as polio vaccination drive starts

Pakistan police officer killed as polio vaccination drive starts
  • Pakistan and neighboring Afghanistan are the only countries where polio is endemic
  • Militants have for decades targeted vaccination teams and their security escorts

PESHAWAR, Pakistan: A Pakistan police officer traveling to guard polio vaccinators was shot dead Monday, police said, on the first day of a nationwide immunization effort after a year of rising cases.
The officer was traveling to guard polio vaccinators in the area of Jamrud town in northwestern Khyber Pakhtunkhwa province when he was killed, local police official Zarmat Khan said.
“Two motorcycle riders opened fire on him,” he said. “The constable died instantly at the scene.”
Pakistan and neighboring Afghanistan are the only countries where polio is endemic and militants have for decades targeted vaccination teams and their security escorts.
Pakistan reported at least 73 polio infections in 2024, a significant increase compared to just six cases in 2023.
The vaccination campaign which started on Monday is the first of the year and is due to last a week.
“Despite the incident, the polio vaccination drive in the area remains ongoing,” Khan said.
Abdul Hameed Afridi, another senior police official in the area, also confirmed details of the attack and said officers have “launched an investigation.”
No group immediately claimed responsibility, however Khyber Pakhtunkhwa – which neighbors Afghanistan – is a hive of militant activity.
The Pakistani Taliban are the most active group in the area.
Polio can easily be prevented by the oral administration of a few drops of vaccine, but scores of vaccination workers and their escorts have been killed over the years.
In the past, clerics falsely claimed that the vaccine contained pork or alcohol, declaring it forbidden for Muslims.
In more recent years the attacks have focused on vulnerable police escorts accompanying the vaccinators as they go door-to-door.
Last year, dozens of Pakistani policemen who accompany medical teams on campaigns went on strike after a string of militant attacks targeting them.
Pakistan has witnessed rising militant attacks since the Taliban returned to power in neighboring Afghanistan.
More than 1,600 people were killed in attacks in 2024 – the deadliest year in almost a decade – according to the Center for Research and Security Studies, an Islamabad-based analysis group.
Islamabad accuses Kabul’s new rulers of failing to rout militants organizing on Afghan soil, a charge the Taliban government routinely denies.
In November, at least seven people – including five children – were killed in a bombing targeting police gathered to guard vaccinators near a school in southwestern Balochistan province.
Balochistan – which also neighbors Afghanistan – was the area with the largest number of polio cases in 2024, despite being the most sparsely populated.
Pakistan’s Prime Minister Shehbaz Sharif said Sunday last year’s polio eradication efforts faced “a major setback.”
“We must eradicate polio from Pakistan at any cost,” he said as he launched the new vaccination drive.


One killed in blast at Moscow residential building, TASS reports

One killed in blast at Moscow residential building, TASS reports
Updated 03 February 2025
Follow

One killed in blast at Moscow residential building, TASS reports

One killed in blast at Moscow residential building, TASS reports

MOSCOW: One person was killed and four people injured in a blast at a residential building in northwest Moscow, Russian state news agency TASS reported on Monday, citing emergency services
Baza, a Telegram channel with contacts in Russia’s security services, published video showing major damage to what it said was the Alye Parusa residential complex, where the blast took place.
It was not immediately clear what had caused the blast.
In December, Ukraine took credit for the killing of Russian General Igor Kirillov in a bomb blast outside a Moscow apartment building.
There was no immediate comment from Ukraine.